Catalog Number: 5084
Chemical Name: 2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one
Biological Activity
Potent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.
Technical Data
  • M.Wt:
    264.32
  • Formula:
    C18H16O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    92831-11-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
    Narwal et al.
    J.Med.Chem., 2013;56:7880

Have you used MN 64?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information