Potent and selective tankyrase (TNKS) inhibitor (IC50
values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50
M). Inhibits WNT/β
-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
Narwal et al.