Catalog Number: 1811
Alternate Names: CRL 40476
Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Biological Activity
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers.
    Ferraro et al.
    Biol.Psychiatry, 1997;42:1181
  2. Antiparkinsonian and neuroprotective effects of modafinil in the mtpt-treated common marmoset.
    Jenner et al.
    Exp.Brain Res., 2000;133:178
  3. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro.
    Madras et al.
    J.Pharmacol.Exp.Ther., 2006;319:561
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