Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Biological ActivityPsychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers.
Ferraro et al.
Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro.
Madras et al.
Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset.
Jenner et al.
Exp.Brain Res., 2000;133:178
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