Montelukast sodium

Catalog # Availability Size / Price Qty
5904/10
5904/50

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Montelukast sodium | CAS No. 151767-02-1 | Leukotriene and Related Receptor Antagonists
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Description: CysLT1 and GPR17 antagonist

Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.

Technical Data

M.Wt:
608.17
Formula:
C35H35ClNNaO3S
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
151767-02-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Montelukast sodium

The citations listed below are publications that use Tocris products. Selected citations for Montelukast sodium include:

1 Citation: Showing 1 - 1

  1. Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
    Authors: Wright Et al.
    Biochem Biophys Res Commun  2019;520:35

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