Cysteinyl leukotriene receptor 1 (CysLT1
) and GPR17 antagonist. Blocks pentylenetetrazole
-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.
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Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction.
Lenz et al.
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.
Marschallinger et al.