Montelukast sodium

Tocris Bioscience | Catalog # 5904

CysLT1 and GPR17 antagonist
Tocris Bioscience
Discontinued Product
5904 has been discontinued. View all Leukotriene and Related Receptor Antagonists products.

Key Product Details

Description

CysLT1 and GPR17 antagonist
View all Leukotriene and Related Receptor Antagonists »

Product Description

Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.

Product Specifications for Montelukast sodium

Molecular Weight

608.17

Formula

C35H35ClNNaO3S

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt

CAS Number

151767-02-1

PubChem ID

23663996

InChI Key

LBFBRXGCXUHRJY-HKHDRNBDSA-M

SMILES

CC(O)(C1=C(C=CC=C1)CC[C@H](C2=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2)SCC5(CC5)CC(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.41 50
DMSO 60.82 100

Preparing Stock Solutions for Montelukast sodium

The following data is based on the product molecular weight 608.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.44 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for Montelukast sodium

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Montelukast sodium

For research use only

Citations for Montelukast sodium

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