Mouse ADAM19 Ectodomain Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB1229U Datasheet / COA / SDS

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FAB1229U-100UG

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Mouse ADAM19 Ectodomain Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse ADAM19 Ectodomain in direct ELISAs and Western blots. It also recognizes a C-terminal fragment (amino acids 588‑705) of recombinant mouse (rm) ADAM19 in Western blots. In Western blots, no cross-reactivity with rmADAM10 or rmADAM15 is observ

Source

Monoclonal Rat IgG2a Clone # 164646

Purification

Protein A or G purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM19 Ectodomain
Asp205-Gly705 (predicted)
Accession # O35674

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ADAM19

ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta ) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to alpha 2-Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin beta chain, TNF-alpha, TRANCE and SCF. Over amino acids (aa) 205‑705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.

Long Name

A Disintegrin and Metalloprotease-like Domain 19

Entrez Gene IDs

8728 (Human); 11492 (Mouse)

Alternate Names

a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM 19; ADAM metallopeptidase domain 19; ADAM19; disintegrin and metalloproteinase domain-containing protein 19; EC 3.4.24; EC 3.4.24.-; MADDAM; Meltrin beta; meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MLTNBmeltrin beta