Mouse APCDD1 (NP_573500) VersaClone cDNA

Name: Mouse APCDD1 (NP_573500) VersaClone cDNA
Brand: R&D Systems
SKU: RDC2396
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC2396

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Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Mouse

Accession Number

NP_573500

Background: APCDD1

Adenomatosis polyposis coli down-regulated 1 protein (APCDD1), also known as DRAPC1, is a negative regulator of the Wnt signaling pathway. APCDD1 acts to inhibit Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin interaction. APCDD-1 is most strongly expressed in pancreas, heart, prostate, ovary, lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. APCDD1 is expressed in both the epidermal and dermal compartments of the hair follicle, and in the dermal papilla, the matrix, and the hair shaft. Mutations in the APCDD1 gene cause hypotrichosis simplex (HTS), a rare form of non-syndromic hereditary hypotrichosis characterized by progressive hairloss in early childhood. The APCDD1 protein has also been found overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1-mutated Wilms tumors.

APCDD1 antibodies may be useful for hair loss studies and research on certian cancers.

Long Name

APC Down Regulated 1

Alternate Names

APC Down Regulated 1, DRAPC1, HYPT1

Entrez Gene IDs

147495 (Human); 494504 (Mouse); 689616 (Rat)

Gene Symbol

APCDD1

UniProt

NP_573500

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Product Specific Notices for Mouse APCDD1 (NP_573500) VersaClone cDNA

For research use only

Related Research Areas

Wnt Inhibitors

Wnt Signaling Modulators

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