Mouse APLP-2 Alexa Fluor® 405-conjugated Antibody

Catalog #: AF3685V Datasheet / COA / SDS

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AF3685V-100UG

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Mouse APLP-2 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse APLP-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) APLP-2 is observed and less than 1% cross-reactivity with rhAPLP-1 and recombinant mouse APLP-1 is observed

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse APLP-2
Leu37-Ser624
Accession # AAH52396.2

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: APLP-2

Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP family of type I transmembrane (TM) proteins. Its 595 aa extracellular region has multiple domains, including an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, and a membrane proximal linker region that contains a GAG attachment site. Several alternatively spliced APLP-2 isoforms have been reported. APLP-2 is proteolytically cleaved by MMPs and secretases and forms both homodimers and heterodimers with APP and APLP-1. Over the range used as immunogen, mouse APLP-2 shares 97% and 91% aa sequence identity with rat and human ALPL-2, respectively.

Long Name

Amyloid Beta [A4] Precursor-like Protein 2

Entrez Gene IDs

334 (Human); 11804 (Mouse); 64312 (Rat)

Alternate Names

amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; Amyloid protein homolog; amyloid-like protein 2; APLP2; APLP-2; APPH; APPHCDEI box-binding protein; APPL2; CDEBP; WALPLP2; YWK-II