C4.4A, also known as LYPD3, is a 65-100 kDa GPI-linked glycoprotein with structural similarity to uPAR. Soluble forms are generated by proteolytic cleavage or released in membrane vesicles. C4.4A is expressed in the suprabasal layers of stratified squamous epithelium, and it is upregulated at the invasive front of melanomas and carcinomas. Metastases derived from these tumors also express high levels of C4.4A. The interaction of C4.4A with Laminin-1 and -5 on neighboring cells promotes the adhesion, spreading, and migration of tumor cells.
Mouse C4.4A/LYPD3 (NP_598504) VersaClone cDNA
R&D Systems | Catalog # RDC2270
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: C4.4A/LYPD3
Long Name
Leucine Rich Repeat and Fibronectin Type III Domain Containing 3
Alternate Names
LYPD3, MIG-C4
Gene Symbol
LYPD3
UniProt
Additional C4.4A/LYPD3 Products
Product Documents for Mouse C4.4A/LYPD3 (NP_598504) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Mouse C4.4A/LYPD3 (NP_598504) VersaClone cDNA
For research use only
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