GDF-15 (Growth Differentiation Factor 15) is a dimeric TGF-beta superfamily cytokine that is highly expressed in placenta and brain. It promotes neuronal survival and regulates neuropeptide Y and pro-opiomelanocortin levels to suppress appetite. It is cardioprotective via inhibition of platelet activation, limiting atherosclerosis, promoting recovery following myocardial infarction, and regulating angiogenesis. GDF-15 also inhibits cartilage formation and the production of TNF-alpha production from LPS-stimulated macrophages.
Mouse GDF-15 (NP_035949.2) VersaClone cDNA
R&D Systems | Catalog # RDC3555
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Background: GDF-15
Long Name
Growth Differentiation Factor 15
Alternate Names
GDF15, MIC-1, NAG-1, PDF, PLAB, PTGF-beta
Gene Symbol
GDF15
UniProt
Additional GDF-15 Products
Product Documents for Mouse GDF-15 (NP_035949.2) VersaClone cDNA
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Product Specific Notices for Mouse GDF-15 (NP_035949.2) VersaClone cDNA
For research use only
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