Mouse GPR20 (NP_775541) VersaClone cDNA Summary
GPR20 is constitutively active in the absence of ligand, leading to continuous activation of its coupled G proteins. When GPR20 was exogenously expressed in HEK293 cells, both the basal level and the prostaglandin E(2)-induced production of cAMP were significantly decreased. Knockdown of GPR20 in PC12h cells resulted in an elevation of the basal cAMP level, suggesting that the endogenous GPR20 achieves a constitutively or spontaneously active conformation. GPR20 may be involved in cellular processes, including control of intracellular cAMP levels and mitogenic signaling.
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