Detection of Integrin beta 4/CD104 in CMT‑93 Mouse Cell Line by Flow Cytometry. CMT‑93 mouse rectal carcinoma cell line was stained with Rat Anti-Mouse Integrin beta 4/CD104 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB4054F, filled histogram) or isotype control antibody (Catalog # IC006F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin beta 4/CD104
Integrin beta 4, also known as CD104, is a 200 kDa type I transmembrane (TM)
glycoprotein that associates only with Integrin alpha 6/CD49f. Integrin alpha 6 beta 4
is predominantly expressed by epithelial cells, binds laminins, and is
essential for formation of hemidesmosomes and connection of the dermis
to the epidermis. Mouse integrin beta 4 contains a 680 amino acid (aa)
extracellular domain (ECD) with a metal-binding site and four
cysteine-rich repeats, a 22 aa TM segment and an unusually long 1073 aa
cytoplasmic tail that organizes hemidesmosome components. Isoforms with
shortened cytoplasmic tails have been described. Mouse and human beta 4 ECD
show 88% aa identity.
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