Mouse MLK3 (NP_071295.2) VersaClone cDNA

R&D Systems | Catalog # RDC3746

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Key Product Details

Species

Mouse

Accession Number

NP_071295.2

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: MLK3

Mixed lineage kinase-3 (MLK-3) is a mitogen-activated kinase kinase kinase that mediates stress-activating protein kinase (SAPK)/c-Jun NH2-terminal kinase activation. MLK-3 and other MLK family kinases are characterized by the presence of multiple protein-protein interaction domains including a tandem leucine/isoleucine zipper (LZs) motif. Leucine zippers are known to mediate protein dimerization raising the possibility that the tandem leucine/isoleucine zippers may function as a dimerization motif of MLK-3 (1). MLK-3 has several interesting structural features including an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. (2). HPK1 has been found to phosphorylate MLK-3 activation loop in vitro, and Ser281 was found to be the major phosphorylation site, indicating that HPK1 also activates MLK-3 via phosphorylation of the kinase activation loop (3).

Long Name

Mixed Lineage Kinase 3

Alternate Names

MAP3K11, PTK1, RHOE, SPRK

Entrez Gene IDs

4296 (Human); 26403 (Mouse); 309168 (Rat)

Gene Symbol

MAP3K11

UniProt

NP_071295.2

Additional MLK3 Products

Product Documents for Mouse MLK3 (NP_071295.2) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Mouse MLK3 (NP_071295.2) VersaClone cDNA

For research use only

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