Orai1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Orai1 is a pore subunit of Ca(2+) release-activated Ca(2+) CRAC channels, and STIM1 acts as an endoplasmic reticulum (ER) Ca(2+) sensor that detects store depletion. This type of channel is the primary way for calcium influx into T-cells. Defects in Orai1 are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1.
Mouse Orai1 (NP_780632) VersaClone cDNA
R&D Systems | Catalog # RDC0826
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Background: Orai1
Long Name
ORAI Calcium Release-activated Calcium Modulator 1
Alternate Names
CRACM1, ORAT1, TMEM142A
Gene Symbol
ORAI1
UniProt
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Product Documents for Mouse Orai1 (NP_780632) VersaClone cDNA
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Product Specific Notices for Mouse Orai1 (NP_780632) VersaClone cDNA
For research use only
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