Plexin A1 is a 200 kDa type I transmembrane member of the Plexin family of Semaphorin signal transducers. It consists of a 1218 amino acid (aa) extracellular domain with one Sema domain, a spacer, and four tandem IPT/TIG domains, a 21 aa transmembrane segment, and a 631 aa cytoplasmic domain. Plexin A1 binds the transmembrane Semaphorin 6D directly and binds the Class 3 secreted Semaphorins indirectly via Neuropilin-1 and -2. It mediates cytoskeletal remodeling that results in cell migration and axon repulsion. Within aa 964 - 1152 (in the IPT/TIG region), human Plexin A1 shares 93% aa sequence identity with mouse and rat Plexin A1.
Mouse Plexin A1 (NP_032907) VersaClone cDNA
R&D Systems | Catalog # RDC0982
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Plexin A1
Alternate Names
NOVP, PLXN1, PLXNA1
Gene Symbol
PLXNA1
UniProt
Additional Plexin A1 Products
Product Documents for Mouse Plexin A1 (NP_032907) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Mouse Plexin A1 (NP_032907) VersaClone cDNA
For research use only
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