Mouse TLR11 PE-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: TLR11

TLR11 is a 110-120 kDa type I transmembrane glycoprotein that belongs to the Toll-like receptor family of proteins that is primarily expressed in intestinal and bladder epithelial cells, dendritic cells, macrophages, astrocytes, neurons and microglia. The 926 amino acid (aa) mouse TLR11 transcript encodes a 30 aa signal sequence, a 691 aa extracellular domain with 10 leucine-rich repeats, a 21 aa transmembrane (TM) domain, and a 184 aa cytoplasmic region with a TIR domain. Within the region used as an immunogen, mouse and rat TLR11 share 86% aa sequence identity. Human TLR11 is a pseudogene that is not expressed. TLR11 resides in the endoplasmic reticulum (ER) where it heterodimerizes with TLR12, and interacts with the 12-TM multispan ER protein UNC93B1, that serves as chaperone and co-factor for TLR11 activity. The receptor recognizes flagelin and profilin from Toxoplasma gondii, plus components of E.coli, S.typhimurium, and promotes IL-12 production by dendritic cells.

Product Datasheets

Related Research Areas

• IL-1 Family
• Immune Regulatory Molecules on Endothelial Cells
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• Pattern Recognition Receptors
• T Cell Antigen Recognition
• Toll-Like Receptors