Mouse WISP2/CCN5 (AAC96320.1) VersaClone cDNA

R&D Systems | Catalog # RDC3744

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Key Product Details

Species

Mouse

Accession Number

AAC96320.1

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: WISP2/CCN5

WISP2 encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Long Name

WNT1 Inducible Signaling Pathway Protein 2

Alternate Names

CCN5, CTGF-L, CTGFL

Entrez Gene IDs

8839 (Human); 22403 (Mouse)

Gene Symbol

CCN5

UniProt

AAC96320.1

Additional WISP2/CCN5 Products

Product Documents for Mouse WISP2/CCN5 (AAC96320.1) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Mouse WISP2/CCN5 (AAC96320.1) VersaClone cDNA

For research use only

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