MP A08

Catalog # Availability Size / Price Qty
5803/10
5803/50
Cat.No. 5803 - MP A08 | C27H25N3O4S2 | CAS No. 219832-49-2
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Description: Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Alternative Names: NSC 122314

Chemical Name: 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide

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Biological Activity

Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Technical Data

M.Wt:
519.64
Formula:
C27H25N3O4S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
219832-49-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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