Mpro 61

Tocris Bioscience | Catalog # 7695

Potent non-covalent inhibitor of SARS-CoV-2 main protease
Tocris Bioscience

Key Product Details

Description

Potent non-covalent inhibitor of SARS-CoV-2 main protease
View all 3C and 3CL Protease Inhibitors »

Product Description

Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC50 = 44 nM, EC50 = 0.175 μM in the replicon assay and EC50 = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.

Licensing Information

Sold under license from Yale University. U.S. patent application number 63/135,062.

Product Specifications for Mpro 61

Molecular Weight

565.38

Formula

C28H19Cl2FN4O4

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6H),3'-bipyridin]-3-yl]-1-methyl-2,4(1H,3H)-pyrimidinedione

CAS Number

2679814-93-6

PubChem ID

156587560

InChI Key

KIJKUSPNZALBLD-UHFFFAOYSA-N

SMILES

CN1C=C(C2=CN(C3=CN=CC=C3)C(C(C4=CC(OCC5=C(C=CC=C5)Cl)=C(C(Cl)=C4)F)=C2)=O)C(NC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.31 20

Preparing Stock Solutions for Mpro 61

The following data is based on the product molecular weight 565.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.84 mL 44.22 mL 88.44 mL
1 mM 1.77 mL 8.84 mL 17.69 mL
2 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.18 mL 0.88 mL 1.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Mpro 61

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Mpro 61

For research use only

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