MPro N3

Key Product Details

Product Description

MPro N3 is a coronavirus main protease (M^pro) inhibitor (respective IC₅₀ values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibits SARS-CoV-2 viral cell entry in a plaque reduction assay (IC₅₀ = 16.8 μM).

Product Specifications for MPro N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MPro N3

The following data is based on the product molecular weight 680.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.94 mL	14.69 mL	29.38 mL
2.5 mM	0.59 mL	2.94 mL	5.88 mL
5 mM	0.29 mL	1.47 mL	2.94 mL
25 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Jin Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 PMID: 32272481
• Yang Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS.One. 2005 PMID: 16128623

Product Documents for MPro N3