Chemical Name: N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
Biological Activityγ-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of Aβ in the brain (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo characterization of Aβ(40) changes in brain and cerebrospinal fluid using the novel γ-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560)
Best et al.
The novel γ-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of Notch-related pathology in the T
Best et al.
Citations for MRK 560
The citations listed below are publications that use Tocris products. Selected citations for MRK 560 include:
3 Citations: Showing 1 - 3
Development of a central nervous system axonal myelination assay for high throughput screening.
Authors: Lariosa-Willingham Et al.
BMC Neurosci 2016;17:16
Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
Authors: Qi Et al.
Acta Neuropathol Commun 2014;2:175
GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation.
Authors: Singh Et al.
Cell Cycle 2014;13:157
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