MRS 1220

Catalog # Availability Size / Price Qty
MRS 1220 | CAS No. 183721-15-5 | Adenosine A3 Receptor Antagonists
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Description: Highly potent and selective hA3 antagonist

Chemical Name: N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide

Purity: ≥98%

Product Details
Citations (13)
Supplemental Products

Biological Activity

MRS 1220 is a potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value > 1 μM for inhibition of binding to rat A3 receptors).

Technical Data

Soluble to 20 mM in DMSO with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the NIH, US Patent 60/029,855

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Citations for MRS 1220

The citations listed below are publications that use Tocris products. Selected citations for MRS 1220 include:

13 Citations: Showing 1 - 10

  1. Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes.
    Authors: Kinoshita Et al.
    EBioMedicine  2018;32:72
  2. Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
    Authors: Liu Et al.
    Brain Res  2018;1700:47
  3. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
    Authors: Torres Et al.
    Oncotarget  2016;7:67373
  4. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X?, P2X?, P2X? channels, P2Y and A? metabotropic receptors in neurotransmission.
    Authors: Liñán-Rico Et al.
    Neuropharmacology  2015;95:83
  5. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  6. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.
    Authors: Corriden Et al.
    FASEB J  2014;28:4211
  7. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
    Authors: Kozma Et al.
    Biochem Pharmacol  2013;85:1171
  8. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
    Authors: Stoddart Et al.
    Chem Biol  2012;19:1105
  9. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    Am J Physiol Gastrointest Liver Physiol  2010;335:781
  10. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.
    Authors: Pugliese Et al.
    Br J Pharmacol  2006;147:524


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