MRS 1220

  ( 11 citations )    
Product Datasheet
Catalog Number:1217
Chemical Name:N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
A potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value > 1 μM for inhibition of binding to rat A3 receptors).
Technical Data
  • M.Wt:
    403.83
  • Formula:
    C21H14ClN5O2
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    183721-15-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the NIH, US Patent 60/029,855
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 1220 include:

11 Citations: Showing 1 - 10
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  1. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
    Authors: Torres Et al.
    Oncotarget  2016;7:67373
  2. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X?, P2X?, P2X? channels, P2Y and A? metabotropic receptors in neurotransmission.
    Authors: Liñán-Rico Et al.
    Neuropharmacology  2015;95:83
  3. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  4. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.
    Authors: Corriden Et al.
    FASEB J  2014;28:4211
  5. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
    Authors: Kozma Et al.
    Biochem Pharmacol  2013;85:1171
  6. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
    Authors: Stoddart Et al.
    Chem Biol  2012;19:1105
  7. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    Am J Physiol Gastrointest Liver Physiol  2010;335:781
  8. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.
    Authors: Pugliese Et al.
    Br J Pharmacol  2006;147:524
  9. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
    Authors: Germack and Dickenson
    Br J Pharmacol  2004;141:329
  10. Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor.
    Authors: Wen and Knowles
    Br J Pharmacol  2003;140:1009
  11. Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation.
    Authors: Man Et al.
    Br J Pharmacol  2003;139:172
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