MRS 1220

Key Product Details

Product Description

MRS 1220 is a potent and highly selective antagonist at the human A₃ adenosine receptor (K_i values are 0.65, 305, and 52 nM at hA₃, rA₁ and rA_2A respectively. Displays an IC₅₀ value > 1 μM for inhibition of binding to rat A₃ receptors).

Licensing Information

Sold with the permission of the NIH, US Patent 60/029,855

Product Specifications for MRS 1220

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MRS 1220

The following data is based on the product molecular weight 403.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.38 mL	61.91 mL	123.81 mL
1 mM	2.48 mL	12.38 mL	24.76 mL
2 mM	1.24 mL	6.19 mL	12.38 mL
10 mM	0.25 mL	1.24 mL	2.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 55 publications citing the usage of this product.

• Kim Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) are selective for the human A₃ receptor subtype. J.Med.Chem. 1996 PMID: 8863790
• Kim Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A_2B and A₃ receptor subtypes. J.Med.Chem. 1998 PMID: 9667972
• Jacobson Pharmacological characterization of novel A₃ adenosine receptor selective antagonists. Neuropharmacology 1997 PMID: 9364471

Product Documents for MRS 1220