Catalog Number: 1584
Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Biological Activity
Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).
Technical Data
  • M.Wt:
    503.56
  • Formula:
    C27H29N5O5
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
    >96%
  • Storage:
    Store at +4°C
  • CAS No:
    264622-53-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Adenosine Therapeutics, LLC
Background References
  1. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
    Kim et al.
    J.Med.Chem., 2000;43:1165
  2. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.
    Li et al.
    J.Pharmacol.Exp.Ther., 2007;320:637
  3. New developments in A1 and A2 adenosine receptor antagonists.
    Kiec-Kononowicz et al.
    Pure Appl.Chem., 2001;73:1411
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 1706 include:

11 Citations: Showing 1 - 10
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  1. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
    Authors: Eusemann Et al.
    PLoS One 2015;10:e0134934
  2. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci 2014;31:237
  3. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol 2013;59:144
  4. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
    Authors: Lee Et al.
    Front Neurosci 2012;63:340
  5. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    J Neurosci 2010;335:781
  6. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells.
    Authors: Mandapathil Et al.
    J Biol Chem 2010;285:7176
  7. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
    Authors: Schneider Et al.
    FASEB J 2010;24:70
  8. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol 2009;47:684
  9. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci 2009;29:11237
  10. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
    Authors: Epperson Et al.
    Am J Physiol Cell Physiol 2009;296:C1171
  11. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Korean J Anesthesiol 2005;25:5502
Expand to show all 11 Citations

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