MRS 1706

Catalog # Availability Size / Price Qty
1584/10
1584/50
MRS 1706 | CAS No. 264622-53-9 | Adenosine A3 Receptor Inverse Agonists
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Description: Potent and selective A2B inverse agonist

Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide

Purity: ≥96%

Product Details
Citations (14)
Supplemental Products
Reviews

Biological Activity

Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).

Technical Data

M.Wt:
503.56
Formula:
C27H29N5O5
Solubility:
Soluble to 5 mM in DMSO
Purity:
≥96%
Storage:
Store at +4°C
CAS No:
264622-53-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Manufactured and sold under license from Adenosine Therapeutics, LLC

Background References

  1. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
    Kim et al.
    J.Med.Chem., 2000;43:1165
  2. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.
    Li et al.
    J.Pharmacol.Exp.Ther., 2007;320:637
  3. New developments in A1 and A2 adenosine receptor antagonists.
    Kiec-Kononowicz et al.
    Pure Appl.Chem., 2001;73:1411

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Citations for MRS 1706

The citations listed below are publications that use Tocris products. Selected citations for MRS 1706 include:

14 Citations: Showing 1 - 10

  1. Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes.
    Authors: Kinoshita Et al.
    EBioMedicine  2018;32:72
  2. An Adenosine Receptor for Olfaction in Fish.
    Authors: Wakisaka Et al.
    Curr Biol  2017;27:1437
  3. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
    Authors: Eusemann Et al.
    PLoS One  2015;10:e0134934
  4. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci  2014;31:237
  5. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol  2013;59:144
  6. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
    Authors: Lee Et al.
    Front Neurosci  2012;63:340
  7. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    J Neurosci  2010;335:781
  8. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells.
    Authors: Mandapathil Et al.
    J Biol Chem  2010;285:7176
  9. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
    Authors: Schneider Et al.
    FASEB J  2010;24:70
  10. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol  2009;47:684

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