Catalog Number: 1584
Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Biological Activity
Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Manufactured and sold under license from Adenosine Therapeutics, LLC
Background References
  1. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors.
    Kim et al.
    J.Med.Chem., 2000;43:1165
  2. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.
    Li et al.
    J.Pharmacol.Exp.Ther., 2007;320:637
  3. New developments in A1 and A2 adenosine receptor antagonists.
    Kiec-Kononowicz et al.
    Pure Appl.Chem., 2001;73:1411

The citations listed below are publications that use Tocris products. Selected citations for MRS 1706 include:

Showing Results 1 - 10 of 11

  1. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
    Authors: Eusemann Et al.
    PLoS One
  2. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
    Authors: Li Et al.
    Vis Neurosci
  3. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol
  4. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
    Authors: Lee Et al.
    Front Neurosci
  5. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    J Neurosci
  6. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells.
    Authors: Mandapathil Et al.
    J Biol Chem
  7. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
    Authors: Schneider Et al.
  8. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
    Authors: Xi Et al.
    J Mol Cell Cardiol
  9. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci
  10. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
    Authors: Epperson Et al.
    Am J Physiol Cell Physiol
  11. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Korean J Anesthesiol
Expand to show all
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information