Catalog Number: 2402
Chemical Name: 2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt
Biological Activity
Competitive P2Y13 receptor antagonist (pIC50 = 5.97) that displays > 20-fold selectivity over P2Y1 and P2Y12 receptors.
Technical Data
  • M.Wt:
    474.66
  • Formula:
    C14H10N4O8Na2PCl
  • Solubility:
    Soluble to 70 mM in water
  • Purity:
    >96%
  • Storage:
    Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor.
    Kim et al.
    Biochem.Pharmacol., 2005;70:266
  2. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.
    Kugelgen
    Pharmacol.Ther., 2006;110:415
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 2211 include:

9 Citations: Showing 1 - 9
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  1. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One 2015;10:e0127919
  2. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
    Authors: Giachini Et al.
    PLoS One 2014;9:e91890
  3. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
    Authors: Wang Et al.
    PLoS One 2014;9:e110101
  4. The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
    Authors: Voss Et al.
    Purinergic Signal 2014;10:455
  5. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Mol Cancer 2013;9:31
  6. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal 2013;11:70
  7. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes.
    Authors: Balduini Et al.
    Haematologica 2012;97:1657
  8. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
    Authors: Puerto Et al.
    J Cell Sci 2012;125:176
  9. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
    Authors: Ohtomo Et al.
    Invest Ophthalmol Vis Sci 2011;52:9503

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