Chemical Name: 2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt
Biological ActivityMRS 2211 is a competitive P2Y13 receptor antagonist (pIC50 = 5.97) that displays > 20-fold selectivity over P2Y1 and P2Y12 receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor.
Kim et al.
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.
Citations for MRS 2211
The citations listed below are publications that use Tocris products. Selected citations for MRS 2211 include:
10 Citations: Showing 1 - 10
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
Authors: Madry Et al.
Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
Authors: Kawano Et al.
PLoS One 2015;10:e0127919
Anti-platelet therapy with clopid. prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
Authors: Giachini Et al.
PLoS One 2014;9:e91890
Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
Authors: Wang Et al.
PLoS One 2014;9:e110101
The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.
Authors: Voss Et al.
Purinergic Signal 2014;10:455
The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
Authors: Gao Et al.
Mol Cancer 2013;9:31
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
Authors: Pinheiro Et al.
Cell Commun Signal 2013;11:70
Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes.
Authors: Balduini Et al.
Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
Authors: Puerto Et al.
J Cell Sci 2012;125:176
Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
Authors: Ohtomo Et al.
Invest Ophthalmol Vis Sci 2011;52:9503
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