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MS 436

Catalog #: 5173 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5173/10
5173/50
MS 436 | CAS No. 1395084-25-9 | Bromodomain Inhibitors
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Description: Potent and selective BRD4(1) inhibitor

Chemical Name: (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

Purity: ≥98%

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Biological Activity

MS 436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro.

Technical Data

M.Wt:
383.42
Formula:
C18H17N5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1395084-25-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Icahn School of Medicine at Mount Sinai.

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