Catalog Number: 0803
Chemical Name: (RS)-α-Methylserine-O-phosphate
Biological Activity
Selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD�of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Also available as part of the Group III mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    199.1
  • Formula:
    C4H10NO6P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    66515-29-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists.
    Thomas et al.
    Neuropharmacology, 1996;35:637
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MSOP include:

5 Citations: Showing 1 - 5
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  1. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.
    Authors: Spaziano Et al.
    Proc Natl Acad Sci U S A 2015;2015:980983
  2. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    J Neurosci 2011;108:9993
  3. Vagal afferent control of opioidergic effects in rat brainstem circuits.
    Authors: Browning Et al.
    Biomed Res Int 2006;575:761
  4. Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
    Authors: Derbenev Et al.
    J Physiol 2006;26:9666
  5. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci 2004;24:4530

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