Highly potent inducer of spermidine/spermine N1
-acetyltransferase, able to increase enzyme activity 200-1000 fold.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts.
Bernacki et al.
Cancer Res., 1992;52:2424
Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs.
Fogel-Petrovic et al.
Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells.
Libby et al.
Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Porter et al.
Cancer Res., 1993;53:581