N¹,N¹¹-Diethylnorspermine tetrahydrochloride

Key Product Details

Product Description

N¹,N¹¹-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N¹-acetyltransferase, able to increase enzyme activity 200-1000 fold.

Product Specifications

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions

The following data is based on the product molecular weight 390.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.81 mL	25.62 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Porter Antitumour activity of N¹,N¹²-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 1993 PMID: 8425191
• Fogel-Petrovic Structural basis for differential induction of spermidine/spermine N¹-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 1997 PMID: 9224814
• Libby Characterization of human spermidine spermine N¹-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 1991 PMID: 1989509
• Bernacki Antitumour activity of N¹,N¹²-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 1992 PMID: 1568212

Product Documents