Catalog Number: 0468
Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride
Biological Activity
Highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts.
    Bernacki et al.
    Cancer Res., 1992;52:2424
  2. Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs.
    Fogel-Petrovic et al.
    Mol.Pharmacol., 1997;52:69
  3. Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells.
    Libby et al.
    Arch.Biochem.Biophys., 1991;284:238
  4. Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
    Porter et al.
    Cancer Res., 1993;53:581
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