Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride
Biological ActivityN1,N11-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs.
Fogel-Petrovic et al.
Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts.
Bernacki et al.
Cancer Res., 1992;52:2424
Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells.
Libby et al.
Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Porter et al.
Cancer Res., 1993;53:581
Citation for N1,N11-Diethylnorspermine tetrahydrochloride
The citations listed below are publications that use Tocris products. Selected citations for N1,N11-Diethylnorspermine tetrahydrochloride include:
1 Citation: Showing 1 - 1
Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Authors: Sandusky-Beltran Et al.
Alzheimers Res Ther 2019;11:58
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