N⁶-Cyclopentyladenosine

Key Product Details

Product Description

N⁶-Cyclopentyladenosine is a potent and selective adenosine A₁ receptor agonist (K_i values are 2.3, 790 and 43 nM for human A₁, A_2A and A₃ receptors respectively; EC₅₀ = 18600 nM for hA_2B). Centrally active following systemic administration in vivo.

Product Specifications for N⁶-Cyclopentyladenosine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for N⁶-Cyclopentyladenosine

The following data is based on the product molecular weight 335.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
• Van der Graaf Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N⁶-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A₁ receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 9353402
• Coffin and Spealman Behavioral and cardiovascular effects of analogs of adenosine in Cynomolgus monkeys. J.Pharmacol.Exp.Ther. 1987 PMID: 3572798

Product Documents for N⁶-Cyclopentyladenosine