Catalog Number: 1702
Alternate Names: CPA
Chemical Name: N-Cyclopentyladenosine
Biological Activity
Potent and selective adenosine A1 receptor agonist (Ki values are 2.3, 790 and 43 nM for human A1, A2A and A3 receptors respectively; EC50 = 18600 nM for hA2B). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    335.36
  • Formula:
    C15H21N5O4
  • Solubility:
    Soluble to 100 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    41552-82-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  2. Behavioral and cardiovascular effects of analogs of adenosine in Cynomolgus monkeys.
    Coffin and Spealman
    J.Pharmacol.Exp.Ther., 1987;241:76
  3. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.
    Van der Graaf et al.
    J.Pharmacol.Exp.Ther., 1997;283:809
Citations:

The citations listed below are publications that use Tocris products. Selected citations for N6-Cyclopentyladenosine include:

6 Citations: Showing 1 - 6
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  1. Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
    Authors: Ledderose Et al.
    Purinergic Signalling 2016;
  2. Role of adenosine receptor subtypes in methamphetamine reward and reinforcement.
    Authors: Kavanagh Et al.
    PLoS One 2015;89:265
  3. Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex.
    Authors: Nguyen Et al.
    PLoS One 2014;9:e87165
  4. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
    Authors: Kozma Et al.
    Biochem Pharmacol 2013;85:1171
  5. Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses.
    Authors: Lemieux Et al.
    J Cell Biol 2012;198:1055
  6. Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
    Authors: Jensen Et al.
    Neuropharmacology 2007;579:85

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