Catalog Number: 5131
Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
Biological Activity
Protects against α-synuclein toxicity. Reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.
Technical Data
  • M.Wt:
    389.88
  • Formula:
    C23H20ClN3O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1504588-00-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.
Background References
  1. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.
    Tardiff et al.
    Science, 2013;342:979
  2. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
    Chung et al.
    Science, 2013;342:983

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