NAB 2

Key Product Details

Product Description

NAB 2 protects against α-synuclein toxicity. NAB 2 reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. NAB 2 promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Product Specifications for NAB 2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NAB 2

The following data is based on the product molecular weight 389.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.82 mL	25.65 mL
5 mM	0.51 mL	2.56 mL	5.13 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Chung Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 2013 PMID: 24158904
• Hatstat Characterization of small-molecule-induced changes in Parkinson's-related trafficking via the Nedd4 ubiquitin signaling cascade. Cell Chem.Biol. 2021 PMID: 33176158
• Tardiff Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 2013 PMID: 24158909

Product Documents for NAB 2