Protects against α
-synuclein toxicity. Reverses the α
-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from Whitehead Institute for Biomedical Research.
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.
Tardiff et al.
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.
Chung et al.