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NAB 2

Catalog #: 5131
2 Citations Datasheet / COA / SDS
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5131/10
5131/50

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NAB 2 | CAS No. 1504588-00-4 | Ubiquitin Ligase (E3) Inhibitors
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Description: Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

NAB 2 protects against α-synuclein toxicity. NAB 2 reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. NAB 2 promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Technical Data

M.Wt:
389.88
Formula:
C23H20ClN3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1504588-00-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.

Product Datasheets

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Citations for NAB 2

The citations listed below are publications that use Tocris products. Selected citations for NAB 2 include:

2 Citations: Showing 1 - 2

  1. Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins.
    Authors: Mayana Et al.
    PLoS Negl Trop Dis  2020;14:e0008424
  2. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475

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