NAD 299 hydrochloride

Key Product Details

Product Description

NAD 299 hydrochloride is a selective, high affinity 5-HT_1A receptor antagonist (K_i = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications for NAD 299 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NAD 299 hydrochloride

The following data is based on the product molecular weight 354.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.09 mL	28.18 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Arborelius The 5-HT_1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur.J.Pharmacol. 1999 PMID: 10528148
• Johansson The pharmacological characterization of a novel selective 5-hydroxytryptamine-_1A receptor antagonist, NAD-299. J.Pharmacol.Exp.Ther. 1997 PMID: 9336327
• Larsson Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT_1A receptor antagonists. Eur.J.Pharmacol. 1998 PMID: 9652362

Product Documents for NAD 299 hydrochloride