NAD 299 hydrochloride

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3282/10
3282/50
NAD 299 hydrochloride | CAS No. 184674-99-5 | 5-HT1A Receptor Antagonists
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Description: Selective, high affinity 5-HT1A antagonist

Chemical Name: (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Reviews

Biological Activity

Selective, high affinity 5-HT1A receptor antagonist (Ki = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.

Technical Data

M.Wt:
354.85
Formula:
C18H23FN2O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
184674-99-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca

Background References

  1. Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists.
    Larsson et al.
    Eur.J.Pharmacol., 1998;346:209
  2. The 5-HT1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing.
    Arborelius et al.
    Eur.J.Pharmacol., 1999;382:133
  3. The pharmacological characterization of a novel selective 5-hydroxytryptamine-1A receptor antagonist, NAD-299.
    Johansson et al.
    J.Pharamacol.Exp.Ther., 1997;283:216

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Citation for NAD 299 hydrochloride

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