NAD 299 hydrochloride
Chemical Name: (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride
Biological ActivitySelective, high affinity 5-HT1A receptor antagonist (Ki = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists.
Larsson et al.
The 5-HT1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing.
Arborelius et al.
The pharmacological characterization of a novel selective 5-hydroxytryptamine-1A receptor antagonist, NAD-299.
Johansson et al.
Citation for NAD 299 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NAD 299 hydrochloride include:
1 Citation: Showing 1 - 1
Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.
Authors: Afshar Et al.
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