NAD 299 hydrochloride
Chemical Name: (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride
Biological ActivityNAD 299 hydrochloride is a selective, high affinity 5-HT1A receptor antagonist (Ki = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists.
Larsson et al.
The 5-HT1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing.
Arborelius et al.
The pharmacological characterization of a novel selective 5-hydroxytryptamine-1A receptor antagonist, NAD-299.
Johansson et al.
Citation for NAD 299 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NAD 299 hydrochloride include:
1 Citation: Showing 1 - 1
Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.
Authors: Afshar Et al.
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