NAI-N3

Name: NAI-N3
Brand: Tocris Bioscience
SKU: 7003

Tocris Bioscience | Catalog # 7003

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Product Documents

Reagent for RNA icSHAPE experiments in vivo

Discontinued Product

7003 has been discontinued. View all General Laboratory Research Reagent products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Reagent for RNA icSHAPE experiments in vivo

View all General Laboratory Research Reagent »

Product Description

NAI-N3 is a probe for icSHAPE (in vivo click selective 2'-hydroxyl acylation and profiling experiment). Acylates the 2'-OH in ssRNA. Enables RNA structure profiling in vivo and ex vivo for all four bases. NAI-N3 can be used for site-specific RNA acylation using the RAIL (RNA Acylation at Induced Loops) method or in Apta-Seq to discover new aptamers in selected pools.

Product Specifications for NAI-N3

Molecular Weight

228.22

Formula

C₁₀H₈N₆O

Storage

Store at -20°C

Chemical Name

[2-(Azidomethyl)-3-pyridinyl]-1H-imidazol-1-ylmethanone

CAS Number

1612756-29-2

PubChem ID

131704490

InChI Key

QPSQVTFTPHUCEH-UHFFFAOYSA-N

SMILES

[N-]=[N+]=NCC1=C(C(N2C=CN=C2)=O)C=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in DMSO (supplied pre-dissolved in DMSO, 1M)

Calculators

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Background References

References are publications that support the biological activity of the product.

Abdelsayed Multiplex aptamer discovery through Apta-Seq and its application to ATP aptamers derived from human-genomic SELEX. ACS Chem.Biol. 2017 PMID: 28661647
Lee Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA 2017 PMID: 27879433
Xiao Site-selective RNA functionalization via DNA-induced structure. J.Am.Chem.Soc. 2020 PMID: 32865995
Spitale Structural imprints in vivo decode RNA regulatory mechanisms. Nature 2015 PMID: 25799993

Product Documents for NAI-N3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for NAI-N3

For research use only

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