Potent, selective antagonist at the rat 5-HT1B
= 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo
. Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neurons
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Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.
Ding et al.
(R)-(+)-2-[[[3-Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl]morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.
Berg et al.
Blockade of 5-HT1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission.
Eriksson et al.
Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor antagonist, NAS-181 in the rat brain.
Stenfors et al.
The citations listed below are publications that use Tocris products. Selected citations for NAS-181 include:
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