NAS-181

Key Product Details

Product Description

NAS-181 is a potent, selective antagonist at the rat 5-HT_1B receptor (K_i = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo. Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neurons

Product Specifications for NAS-181

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NAS-181

The following data is based on the product molecular weight 538.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.28 mL	18.57 mL
5 mM	0.37 mL	1.86 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Ding Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection. J.Neurosci. 2013 PMID: 23486958
• Eriksson Blockade of 5-HT_1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission. Neuropharmacology 2008 PMID: 18394658
• Stenfors Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT_1B receptor antagonist, NAS-181 in the rat brain. Neuropharmacology 2000 PMID: 10728876
• Berg (R)-(+)-2-[[[3-Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl]morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine_1B receptor antagonist. J.Med.Chem. 1998 PMID: 9599242

Product Documents for NAS-181