NAS-181
Chemical Name: (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate
Purity: ≥97%
Biological Activity
NAS-181 is a potent, selective antagonist at the rat 5-HT1B receptor (Ki = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo. Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neuronsTechnical Data
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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(R)-(+)-2-[[[3-Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl]morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.
Berg et al.
J.Med.Chem., 1998;41:1934 -
Blockade of 5-HT1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission.
Eriksson et al.
Neuropharmacology, 2008;54:1041 -
Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor antagonist, NAS-181 in the rat brain.
Stenfors et al.
Neuropharmacology, 2000;39:553 -
Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.
Ding et al.
J.Neurosci., 2013;33:4875
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Citation for NAS-181
The citations listed below are publications that use Tocris products. Selected citations for NAS-181 include:
1 Citation: Showing 1 - 1
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Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
Authors: Xiao Et al.
Neuron 2008;4:12
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