Chemical Name: N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Biological ActivityNaspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen and England
Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia.
Tsubokawa et al.
Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons.
Koike et al.
Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death.
Noh et al.
Citations for Naspm trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Naspm trihydrochloride include:
13 Citations: Showing 1 - 10
M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
Authors: Zhang Et al.
Cell Rep 2019;27:2871
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Authors: Purkey Et al.
Cell Rep 2018;25:974
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
Authors: Park Et al.
J Neurosci 2016;36:622
Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
Authors: Megill Et al.
In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
Authors: Fernandes Et al.
PLoS One 2014;9:e99958
Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
Authors: Roy Et al.
J Neurosci 2014;9:e101883
Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
Authors: Lee Et al.
J Cereb Blood Flow Metab 2014;509:195
Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Authors: Blanco-Suárez Et al.
Nat Commun 2014;34:1898
Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
Authors: Kim and Ziff
PLoS Biol 2014;12:e1001900
Pain after discontinuation of mor. treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
Authors: Cabañero Et al.
Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Authors: Liu Et al.
J Neurophysiol 2013;110:505
Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
Authors: Villers Et al.
PLoS One 2012;7:e40823
PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
Authors: Jaafari Et al.
J Neurosci 2012;32:11618
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used to block calcium permeable AMPA receptors in spinal cord neurons at a concentration of 25 micromolar