Naspm trihydrochloride

  ( 10 citations )    
Product Datasheet
Catalog Number:2766
Alternate Names:1-Naphthyl acetyl spermine trihydrochloride
Chemical Name:N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Product Details
Citations (10)
Reviews
Biological Activity
Selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
Technical Data
  • M.Wt:
    479.91
  • Formula:
    C22H34N4O.3HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >97
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1049731-36-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Naspm trihydrochloride include:

10 Citations: Showing 1 - 10
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  1. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci  2016;36:622
  2. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
    Authors: Megill Et al.
    Nature  2015;35:11346
  3. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
    Authors: Fernandes Et al.
    PLoS One  2014;9:e99958
  4. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
    Authors: Roy Et al.
    J Neurosci  2014;9:e101883
  5. Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
    Authors: Lee Et al.
    J Cereb Blood Flow Metab  2014;509:195
  6. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
    Authors: Blanco-Suárez Et al.
    Nat Commun  2014;34:1898
  7. Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
    Authors: Kim and Ziff
    PLoS Biol  2014;12:e1001900
  8. Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
    Authors: Cabañero Et al.
    Neuropsychopharmacology  2013;38:1472
  9. Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
    Authors: Villers Et al.
    PLoS One  2012;7:e40823
  10. PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
    Authors: Jaafari Et al.
    J Neurosci  2012;32:11618

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