Naspm trihydrochloride

Tocris Bioscience | Catalog # 2766

Ca2+-permeable AMPA antagonist
Tocris Bioscience

Key Product Details

Description

Ca2+-permeable AMPA antagonist

Alternative Names

1-Naphthyl acetyl spermine trihydrochloride
View all AMPA Receptor Antagonists »

Product Description

Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.

Product Specifications for Naspm trihydrochloride

Molecular Weight

479.91

Formula

C22H34N4O.3HCl

Storage

Desiccate at +4°C

Purity

≥97% (HPLC)

Chemical Name

N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride

CAS Number

1049731-36-3

PubChem ID

16219727

InChI Key

JNEOJAUJWOPWJS-UHFFFAOYSA-N

SMILES

O=C(NCCCNCCCCNCCCN)CC2=CC=CC1=CC=CC=C12.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 47.99 100

Preparing Stock Solutions for Naspm trihydrochloride

The following data is based on the product molecular weight 479.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 52 publications citing the usage of this product.

Product Documents for Naspm trihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Naspm trihydrochloride

For research use only

Citations for Naspm trihydrochloride

Customer Reviews for Naspm trihydrochloride (1)

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  • calcium permeable AMPA receptor blocker
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: spinal cord neurons
    Verified Customer | Posted 11/02/2018
    used to block calcium permeable AMPA receptors in spinal cord neurons at a concentration of 25 micromolar
    Naspm trihydrochloride 2766

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