Naspm trihydrochloride

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Naspm trihydrochloride | CAS No. 1049731-36-3 | AMPA Receptor Antagonists
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Description: Ca2+-permeable AMPA antagonist
Alternative Names: 1-Naphthyl acetyl spermine trihydrochloride

Chemical Name: N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride

Purity: ≥97%

Product Details
Citations (13)

Biological Activity

Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.

Technical Data

Soluble to 100 mM in water
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A subtype-selective, use-dependent inhibitor of native AMPA receptors.
    Nilsen and England
    J.Am.Chem.Soc., 2007;129:4902
  2. Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia.
    Tsubokawa et al.
    J.Neurophysiol., 1995;74:218
  3. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons.
    Koike et al.
    Neurosci.Res., 1997;29:27
  4. Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death.
    Noh et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:12230

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Citations for Naspm trihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Naspm trihydrochloride include:

13 Citations: Showing 1 - 10

  1. M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
    Authors: Zhang Et al.
    Cell Rep  2019;27:2871
  2. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
    Authors: Purkey Et al.
    Cell Rep  2018;25:974
  3. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci  2016;36:622
  4. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
    Authors: Megill Et al.
    Nature  2015;35:11346
  5. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
    Authors: Fernandes Et al.
    PLoS One  2014;9:e99958
  6. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
    Authors: Roy Et al.
    J Neurosci  2014;9:e101883
  7. Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
    Authors: Lee Et al.
    J Cereb Blood Flow Metab  2014;509:195
  8. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
    Authors: Blanco-Suárez Et al.
    Nat Commun  2014;34:1898
  9. Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
    Authors: Kim and Ziff
    PLoS Biol  2014;12:e1001900
  10. Pain after discontinuation of mor. treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
    Authors: Cabañero Et al.
    Neuropsychopharmacology  2013;38:1472


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