Chemical Name: N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Biological ActivitySelective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen and England
Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia.
Tsubokawa et al.
Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons.
Koike et al.
Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death.
Noh et al.
Citations for Naspm trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Naspm trihydrochloride include:
13 Citations: Showing 1 - 10
M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
Authors: Zhang Et al.
Cell Rep 2019;27:2871
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Authors: Purkey Et al.
Cell Rep 2018;25:974
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
Authors: Park Et al.
J Neurosci 2016;36:622
Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
Authors: Megill Et al.
In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
Authors: Fernandes Et al.
PLoS One 2014;9:e99958
Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
Authors: Roy Et al.
J Neurosci 2014;9:e101883
Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
Authors: Lee Et al.
J Cereb Blood Flow Metab 2014;509:195
Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Authors: Blanco-Suárez Et al.
Nat Commun 2014;34:1898
Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
Authors: Kim and Ziff
PLoS Biol 2014;12:e1001900
Pain after discontinuation of mor. treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
Authors: Cabañero Et al.
Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Authors: Liu Et al.
J Neurophysiol 2013;110:505
Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
Authors: Villers Et al.
PLoS One 2012;7:e40823
PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
Authors: Jaafari Et al.
J Neurosci 2012;32:11618
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Naspm trihydrochloride
Average Rating: 5 (Based on 1 Review)
Have you used Naspm trihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
used to block calcium permeable AMPA receptors in spinal cord neurons at a concentration of 25 micromolar