Catalog Number: 2766
Alternate Names: 1-Naphthyl acetyl spermine trihydrochloride
Chemical Name: N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Biological Activity
Selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluR2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A subtype-selective, use-dependent inhibitor of native AMPA receptors.
    Nilsen and England
    J.Am.Chem.Soc., 2007;129:4902
  2. Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia.
    Tsubokawa et al.
    J.Neurophysiol., 1995;74:218
  3. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons.
    Koike et al.
    Neurosci.Res., 1997;29:27
  4. Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death.
    Noh et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:12230

The citations listed below are publications that use Tocris products. Selected citations for Naspm trihydrochloride include:

Showing Results 1 - 10 of 10

  1. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci
  2. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease.
    Authors: Megill Et al.
  3. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons.
    Authors: Fernandes Et al.
    PLoS One
  4. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase.
    Authors: Roy Et al.
    J Neurosci
  5. Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
    Authors: Lee Et al.
    J Cereb Blood Flow Metab
  6. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
    Authors: Blanco-Suárez Et al.
    Nat Commun
  7. Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.
    Authors: Kim and Ziff
    PLoS Biol
  8. Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.
    Authors: Cabañero Et al.
  9. Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
    Authors: Villers Et al.
    PLoS One
  10. PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
    Authors: Jaafari Et al.
    J Neurosci
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