Catalog Number: 5171
Alternate Names: 25CN-NBOH
Chemical Name: 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride
Biological Activity
High affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.
Technical Data
  • M.Wt:
    348.82
  • Formula:
    C18H20N2O3.HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1539266-32-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice.
    Fantegrossi et al.
    Psychopharmacology (Berl.), 2014;
  2. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.
    Hansen et al.
    ACS.Chem.Neurosci., 2014;5:243

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