NBOH-2C-CN hydrochloride

Key Product Details

Product Description

NBOH-2C-CN hydrochloride is a high affinity, selective 5-HT_2A agonist (K_i = 1.3 nM). Exhibits 100-fold selectivity for 5-HT_2A over 5-HT_2C. Elicits head twitch behavior in mice.

Product Specifications for NBOH-2C-CN hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NBOH-2C-CN hydrochloride

The following data is based on the product molecular weight 348.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.33 mL	28.67 mL
5 mM	0.57 mL	2.87 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Jensen The selective 5-HT_2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [ ³H]25CN-NBOH. Biochem.Pharmacol. 2020 PMID: 32298690
• Fantegrossi Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT_2A receptors, in mice. Psychopharmacology (Berl.) 2014 PMID: 25224567
• Jensen Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT_2A receptor agonist. J.Pharmacol.Exp.Ther 2017 PMID: 28360333
• Hansen Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT_2A/2C agonists. ACS.Chem.Neurosci. 2014 PMID: 24397362

Product Documents for NBOH-2C-CN hydrochloride