NCT 02

Key Product Details

Product Description

NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC₅₀ ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.

Product Specifications for NCT 02

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NCT 02

The following data is based on the product molecular weight 312.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.01 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dieter Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021 PMID: 34289372

Product Documents for NCT 02