Highly selective β1
-adrenoceptor antagonist (Ki
values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1
receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50
= 11.36 μ
M in renal arteries) and displays antihypertensive activity in vivo
-arrestin biased agonist at the β
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The �-blocker Nebivolol Is a GRK/�-arrestin biased agonist.
Erickson et al.
PLoS One, 2013;8:e71980
The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various β-adrenergic blockers.
Pauwels et al.
Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors.
Georgescu et al.
The citations listed below are publications that use Tocris products. Selected citations for Nebivolol hydrochloride include:
Showing Results 1 - 1 of 1