Chemical Name: (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Biological ActivityNebivolol hydrochloride is a highly selective β1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1, 5-HT1A, β2, 5-HT2, α1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors.
Georgescu et al.
The �-blocker nebi. Is a GRK/�-arrestin biased agonist.
Erickson et al.
PLoS One, 2013;8:e71980
The receptor binding profile of the new antihypertensive agent nebi. and its stereoisomers compared with various β-adrenergic blockers.
Pauwels et al.
Citation for Nebivolol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Nebivolol hydrochloride include:
1 Citation: Showing 1 - 1
Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
Authors: Littmann Et al.
Brain Res 2015;355:183
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