Catalog Number: 5025
Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
Biological Activity
Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.
Technical Data
  • M.Wt:
    461.47
  • Formula:
    C18H15N5O6S2
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1360614-48-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. New components of the necroptotic pathway.
    Zhou et al.
    Protein Cell, 2012;3:811
  2. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
    Sun et al.
    Cell, 2012;148:213
  3. Killing a cancer: what are the alternatives?
    Kreuzaler et al.
    Nat.Rev.Cancer., 2012;12:411
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Necrosulfonamide include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Death receptor 3 mediates necroptotic cell death
    Authors: Bittner Et al.
    Cellular and Molecular Life Sciences 2016;
  2. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
    Authors: Gonzalez-Juarbe Et al.
    Channels (Austin) 2015;11:e1005337

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