Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.
Soluble to 20 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
New components of the necroptotic pathway.
Zhou et al.
Protein Cell, 2012;3:811
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
Sun et al.
Killing a cancer: what are the alternatives?
Kreuzaler et al.
The citations listed below are publications that use Tocris products. Selected citations for Necrosulfonamide include:
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