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Necrosulfonamide | CAS No. 1360614-48-7 | Additional Apoptosis-related Compounds
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Description: Necroptosis inhibitor; also inhibits pyroptosis

Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Purity: ≥98%

Product Details
Citations (19)
Supplemental Products

Biological Activity

Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New components of the necroptotic pathway.
    Zhou et al.
    Protein Cell, 2012;3:811
  2. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
    Sun et al.
    Cell, 2012;148:213
  3. Killing a cancer: what are the alternatives?
    Kreuzaler et al.
    Nat.Rev.Cancer., 2012;12:411
  4. Gasdermin D (GSDMD) as a new target for the treatment of infection.
    Pandeya et al.
    Medchemcomm, 2019;10:660

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Citations for Necrosulfonamide

The citations listed below are publications that use Tocris products. Selected citations for Necrosulfonamide include:

19 Citations: Showing 1 - 10

  1. PRMT5-mediated regulatory arginine methylation of RIPK3.
    Authors: Simon Et al.
    Cell Death Discov  2023;9:14
  2. Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine's inhibitory effects on necroptotic kinases.
    Authors: Yuan Et al.
    Front Pharmacol  2023;13:1060954
  3. A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.
    Authors: Svetlana Et al.
    Cell  2022;185:2354-2369.e17
  4. RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
    Authors: Junying Et al.
    Mol Cell  2021;81:370-385.e7
  5. Caspase-9 acts as a regulator of necroptotic cell death.
    Authors: Ferenc Et al.
    FEBS J  2021;288:6476-6491
  6. Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
    Authors: Michael E Et al.
    Elife  2021;10
  7. Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis.
    Authors: Kevin S Et al.
    Cell Rep  2020;32:108062
  8. Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.
    Authors: Kyung-Min Et al.
    Breast Cancer Res  2020;22:130
  9. Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis.
    Authors: Tanya A Et al.
    Viruses  2020;12
  10. Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
    Authors: James Et al.
    Proc Natl Acad Sci U S A  2020;117:33272-33281
  11. Necroptosis in primate luteolysis: a role for ceramide.
    Authors: Bagnjuk Et al.
    Cell Death Discov  2019;5:67
  12. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
    Authors: Chefetz Et al.
    Cell Rep  2019;26:3061
  13. Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells.
    Authors: Charles E Et al.
    Biochim Biophys Acta Mol Cell Biol Lipids  2019;1864:158-167
  14. ONC201 kills breast cancer cells in vitro by targeting mitochondria.
    Authors: Greer Et al.
    Oncotarget  2018;9:18454
  15. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.
    Authors: Gonzalez-Juarbe Et al.
    Cell Death Differ  2017;24:917
  16. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.
    Authors: Xie Et al.
    Cell Rep  2017;20:1692
  17. The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.
    Authors: Heulot Et al.
    Oncotarget  2016;7:64342
  18. Death receptor 3 mediates necroptotic cell death.
    Authors: Bittner Et al.
    Cellular and Molecular Life Sciences  2016;
  19. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
    Authors: Gonzalez-Juarbe Et al.
    Channels (Austin)  2015;11:e1005337


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