Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
Biological ActivityNecrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
New components of the necroptotic pathway.
Zhou et al.
Protein Cell, 2012;3:811
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
Sun et al.
Killing a cancer: what are the alternatives?
Kreuzaler et al.
Gasdermin D (GSDMD) as a new target for the treatment of infection.
Pandeya et al.
Citations for Necrosulfonamide
The citations listed below are publications that use Tocris products. Selected citations for Necrosulfonamide include:
19 Citations: Showing 1 - 10
PRMT5-mediated regulatory arginine methylation of RIPK3.
Authors: Simon Et al.
Cell Death Discov 2023;9:14
Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine's inhibitory effects on necroptotic kinases.
Authors: Yuan Et al.
Front Pharmacol 2023;13:1060954
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.
Authors: Svetlana Et al.
RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
Authors: Junying Et al.
Mol Cell 2021;81:370-385.e7
Caspase-9 acts as a regulator of necroptotic cell death.
Authors: Ferenc Et al.
FEBS J 2021;288:6476-6491
Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
Authors: Michael E Et al.
Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis.
Authors: Kevin S Et al.
Cell Rep 2020;32:108062
Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.
Authors: Kyung-Min Et al.
Breast Cancer Res 2020;22:130
Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis.
Authors: Tanya A Et al.
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Authors: James Et al.
Proc Natl Acad Sci U S A 2020;117:33272-33281
Necroptosis in primate luteolysis: a role for ceramide.
Authors: Bagnjuk Et al.
Cell Death Discov 2019;5:67
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Authors: Chefetz Et al.
Cell Rep 2019;26:3061
Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells.
Authors: Charles E Et al.
Biochim Biophys Acta Mol Cell Biol Lipids 2019;1864:158-167
ONC201 kills breast cancer cells in vitro by targeting mitochondria.
Authors: Greer Et al.
Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.
Authors: Gonzalez-Juarbe Et al.
Cell Death Differ 2017;24:917
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.
Authors: Xie Et al.
Cell Rep 2017;20:1692
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.
Authors: Heulot Et al.
Death receptor 3 mediates necroptotic cell death.
Authors: Bittner Et al.
Cellular and Molecular Life Sciences 2016;
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Authors: Gonzalez-Juarbe Et al.
Channels (Austin) 2015;11:e1005337
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