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Necrosulfonamide | CAS No. 1360614-48-7 | Additional Apoptosis-related Compounds
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Description: Necroptosis inhibitor; also inhibits pyroptosis

Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Purity: ≥98%

Product Details
Citations (8)
Supplemental Products

Biological Activity

Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New components of the necroptotic pathway.
    Zhou et al.
    Protein Cell, 2012;3:811
  2. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
    Sun et al.
    Cell, 2012;148:213
  3. Killing a cancer: what are the alternatives?
    Kreuzaler et al.
    Nat.Rev.Cancer., 2012;12:411
  4. Gasdermin D (GSDMD) as a new target for the treatment of infection.
    Pandeya et al.
    Medchemcomm, 2019;10:660

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Citations for Necrosulfonamide

The citations listed below are publications that use Tocris products. Selected citations for Necrosulfonamide include:

8 Citations: Showing 1 - 8


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