5 results for "Necroptosis Compounds" in Products
Necroptosis Compounds
Necroptosis is initiated by activation of TNFR1, which induces the formation of a complex (complex I), comprising the TNFR-associated death protein (TRADD) and RIP1 kinase. Deubiquitination of RIP1 enables its release from complex I, which then forms a complex with RIP3, known as the necrosome. The assembly of the necrosome is dependent on caspase 8 inactivation and the release of RIP1 from complex I. Active RIP3 then catalyzes the phosphorylation of MLKL leading to oligomerization of MLKL; ...
RIP1 kinase inhibitor; inhibits necroptosis
| Chemical Name: | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Purity: | ≥98% |
Necroptosis inhibitor; also inhibits pyroptosis
| Chemical Name: | (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide |
| Purity: | ≥98% |
Potent and selective RIP3 kinase inhibitor
| Chemical Name: | N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine |
| Purity: | ≥98% |
Potent and metabolically stable RIP1 kinase inhibitor
| Chemical Name: | N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide |
| Purity: | ≥98% |
Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
| Chemical Name: | 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride |
| Purity: | ≥98% |
