NAADP inhibitor. Prevents Ca2+
oscillations in rat cardiomyocytes in vitro
during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+
sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo
Soluble to 50 mM in DMSO
Store at -20°C
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Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.
Davidson et al.