Nelarabine

Key Product Details

Product Description

Nelarabine is a nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.

Product Specifications for Nelarabine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nelarabine

The following data is based on the product molecular weight 297.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.82 mL	33.64 mL
5 mM	0.67 mL	3.36 mL	6.73 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Beesley In vitro cytotoxicity of nelarabine, clofar. and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 2007 PMID: 17391490
• Reilly and Kisor Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2009 PMID: 20616909
• Lambe 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 1995 PMID: 7614470

Product Documents for Nelarabine