Chemical Name: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Biological ActivityNelarabine is a nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.
Lambe et al.
Cancer Res., 1995;55:3352
Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia.
Reilly and Kisor et al.
OncoTargets Ther., 2009;2:219
In vitro cytotoxicity of nelarabine, clofar. and flavopiridol in paediatric acute lymphoblastic leukaemia.
Beesley et al.
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