Neuropeptide AF (human)
Biological ActivityEndogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonist
(Modifications: Phe-18 = C-terminal amide)
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Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.
Elshourbagy et al.
Neuropeptide AF and FF modulation of adipocyte metabolism.
Lefrere et al.
Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli.
Vilim et al.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
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