Neuropeptide AF (human)
Biological ActivityNeuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonist
(Modifications: Phe-18 = C-terminal amide)
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Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.
Elshourbagy et al.
Neuropeptide AF and FF modulation of adipocyte metabolism.
Lefrere et al.
Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli.
Vilim et al.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
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