Neuropeptide AF (human)
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Description: Endogenous NPFF1 and NPFF2 agonist; antiopioid neuropeptide and MRGPRA agonist
Alternative Names: NPAF, Neuropeptide NPAF (human FMRFamide-related)
Biological Activity
Neuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonistTechnical Data
M.Wt:
1978.19
Formula:
C90H132N26O25
Sequence:
AGEGLNSQFWSLAAPQRF
(Modifications: Phe-18 = C-terminal amide)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
192387-38-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.
Elshourbagy et al.
J.Biol.Chem., 2000;275:25965 -
Neuropeptide AF and FF modulation of adipocyte metabolism.
Lefrere et al.
J.Biol.Chem., 2002;277:39169 -
Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli.
Vilim et al.
Mol.Pharmacol., 1999;55:804 -
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
Pharmacol.Rev., 2014;66:570
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