Biological ActivityNeuropeptide FF is an endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration. Also MRGPRA agonist.
(Modifications: Phe-8 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks.
Cline et al.
Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[35S]GTPγS binding.
Gouarderes et al.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
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VersaClone cDNA Plasmids
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