NG 25

Tocris Bioscience | Catalog # 5429

TGF-β-activated kinase (TAK1) inhibitor
Tocris Bioscience

Key Product Details

Description

TGF-β-activated kinase (TAK1) inhibitor
View all Other Kinase Inhibitors »

Product Description

NG 25 is a TGF-β-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-α and TLR7/8 agonist CL097-stimulated secretion of IFN-β in Gen 2.2 leukemia cells in vitro.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for NG 25

Molecular Weight

537.58

Formula

C29H30F3N5O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

CAS Number

1315355-93-1

PubChem ID

53340664

InChI Key

SMPGEBOIKULBCT-UHFFFAOYSA-N

SMILES

CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(OC4=CC=NC5=C4C=CN5)=C(C)C=C3)=O)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.75 20

Preparing Stock Solutions for NG 25

The following data is based on the product molecular weight 537.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.30 mL 46.50 mL 93.01 mL
1 mM 1.86 mL 9.30 mL 18.60 mL
2 mM 0.93 mL 4.65 mL 9.30 mL
10 mM 0.19 mL 0.93 mL 1.86 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for NG 25

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NG 25

For research use only

Customer Reviews for NG 25 (1)

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  • Works for kinase assays
    Name: Scott Scarneo
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/06/2019
    Worked in vitro Kinase assay compared to other TAK1 inhibitors.
    NG 25 5429

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