Potent and selective dopamine D3
receptor antagonist (Ki
values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3
receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50
= 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
Xi et al.
NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.
Yuan et al.
The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion.
Pritchard et al.
The citations listed below are publications that use Tocris products. Selected citations for NGB 2904 include:
Showing Results 1 - 1 of 1