NGB 2904

Key Product Details

Product Description

NGB 2904 is a potent and selective dopamine D₃ receptor antagonist (K_i values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D₃, D₂, 5-HT₂, α₁, D₄, D₁ and D₅ receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC₅₀ = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Product Specifications for NGB 2904

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NGB 2904

The following data is based on the product molecular weight 530.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.53 mL	37.67 mL	75.34 mL
1.25 mM	1.51 mL	7.53 mL	15.07 mL
2.5 mM	0.75 mL	3.77 mL	7.53 mL
12.5 mM	0.15 mL	0.75 mL	1.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Xi The novel DA D₃ receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 2006 PMID: 16205781
• Pritchard The DA D₃ receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 2007 PMID: 17408730
• Yuan NGB 2904 and NGB 2849: two highly selective DA D₃ receptor antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9873609

Product Documents for NGB 2904