Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
Biological ActivityNGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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NGB 2904 and NGB 2849: two highly selective DA D3 receptor antagonists.
Yuan et al.
The novel DA D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
Xi et al.
The DA D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion.
Pritchard et al.
Citations for NGB 2904
The citations listed below are publications that use Tocris products. Selected citations for NGB 2904 include:
2 Citations: Showing 1 - 2
Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and DA D1 receptor pathways in the diet-induced obese rat.
Authors: Axel Et al.
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