Catalog Number: 2635
Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
Biological Activity
Potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
Technical Data
  • M.Wt:
    530.92
  • Formula:
    C28H29Cl2N3O.HCl
  • Solubility:
    Soluble to 25 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    189061-11-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
    Xi et al.
    Neuropsychopharmacology, 2006;31:1393
  2. NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.
    Yuan et al.
    Bioorg.Med.Chem.Lett., 1998;8:2715
  3. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion.
    Pritchard et al.
    Pharmacol.Biochem.Behav., 2007;86:718
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NGB 2904 include:

1 Citations: Showing 1 - 1

  1. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.
    Authors: Axel Et al.
    Neuropsychopharmacology 2010;35:1464

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