Chemical Name: 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzene-1-sulfonamide
Biological ActivityPotent and selective BRPF bromodomain inhibitor (Kd values are 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively. Exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins.
Igoe et al.
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