Chemical Name: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Biological ActivityNiclosamide is an inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Niclosamide displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. It inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. It also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. In addition, niclosamide inhibits SARS-CoV-2 replication in vitro (IC50 = 0.34 μM in Vero E6 plaque assay) through suppression of TMEM16F activity.
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Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Balgi et al.
PLoS One, 2009;4:e7124
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-κB pathway and generation of reactive oxygen species.
Jin et al.
Cancer Res., 2010;70:2516
Citation for Niclosamide
The citations listed below are publications that use Tocris products. Selected citations for Niclosamide include:
1 Citation: Showing 1 - 1
STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
Authors: Natarajan Et al.
PLoS One 2014;9:e100405
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