Niclosamide

  ( 1 citations )    
Product Datasheet
Catalog Number:4079
Chemical Name:5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Product Details
Citations (1)
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Reviews
Biological Activity
Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Technical Data
  • M.Wt:
    325.99
  • Formula:
    C13H8Cl2N2O4
  • Solubility:
    Soluble to 25 mM in ethanol and to 10 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    50-65-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Niclosamide include:

1 Citations: Showing 1 - 1

  1. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
    Authors: Natarajan Et al.
    PLoS One  2014;9:e100405

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