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Nimesulide

Catalog #: 2470
3 Citations Datasheet / COA / SDS

Discontinued Product

2470 has been discontinued.
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Nimesulide | CAS No. 51803-78-2 | Cyclooxygenase Inhibitors
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Description: Cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: Flogovital,Aulin

Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Nimesulide is a selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs. Also inhibits sodium-dependent neutral amino acid transporter B0AT1 (SLC6A19; IC50 = 23 μM).

Technical Data

M.Wt:
308.31
Formula:
C13H12N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
51803-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Nimesulide

The citations listed below are publications that use Tocris products. Selected citations for Nimesulide include:

3 Citations: Showing 1 - 3

  1. Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries.
    Authors: Baranowska-Kuczko Et al.
    J Neuroimmune Pharmacol  2014;387:477
  2. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase.
    Authors: Anneken Et al.
    Nat Commun  2013;8:58
  3. Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids.
    Authors: Staniaszek Et al.
    Br J Pharmacol  2010;160:669

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