Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Biological ActivityNimesulide is a selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs. Also inhibits sodium-dependent neutral amino acid transporter B0AT1 (SLC6A19; IC50 = 23 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
Selective cyclooxygenase-2 inhibition by nimesulide in man.
Cullen et al.
Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling.
Pochini et al.
Citations for Nimesulide
The citations listed below are publications that use Tocris products. Selected citations for Nimesulide include:
3 Citations: Showing 1 - 3
Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries.
Authors: Baranowska-Kuczko Et al.
J Neuroimmune Pharmacol 2014;387:477
MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase.
Authors: Anneken Et al.
Nat Commun 2013;8:58
Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids.
Authors: Staniaszek Et al.
Br J Pharmacol 2010;160:669
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