Catalog Number: 2470
Alternate Names: Flogovital, Aulin
Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Biological Activity
Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs.��.
Technical Data
  • M.Wt:
    308.31
  • Formula:
    C13H12N2O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    51803-78-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview.
    Famaey
    Inflamm.Res., 1997;46:437
  2. Selective cyclooxygenase-2 inhibition by nimesulide in man.
    Cullen et al.
    J.Pharmacol.Exp.Ther., 1998;287:578
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nimesulide include:

3 Citations: Showing 1 - 3
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  1. Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries.
    Authors: Baranowska-Kuczko Et al.
    J Neuroimmune Pharmacol 2014;387:477
  2. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase.
    Authors: Anneken Et al.
    Nat Commun 2013;8:58
  3. Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids.
    Authors: Staniaszek Et al.
    Br J Pharmacol 2010;160:669

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