Chemical Name: 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Biological ActivityPyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC50 = 2.12μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Wang et al.
Cell Research, 2020;30:269
Update on Nitazoxanide: a multifunctional chemotherapeutic agent.
Shakya et al.
Curr.Drug Discov.Technol., 2018;15:201
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.
Qu et al.
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