[Nle4,D-Phe7]-α-MSH

Catalog # Availability Size / Price Qty
3013/1
[Nle4,D-Phe7]-α-MSH
1 Image
Description: Melanocortin receptor agonist
Alternative Names: Melanotan I, MT-I, NDP-α-MSH
Product Details
Citations (1)
Reviews

Biological Activity

Synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).

Technical Data

M.Wt:
1646.86
Formula:
C78H111N21O19
Sequence:
SYSXEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)

Solubility:
Soluble to 0.60 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
75921-69-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Melanocortin receptors: perspectives for novel drugs.
    Wikber
    Eur.J.Pharmacol., 1999;375:295
  2. 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity.
    Sawyer et al.
    Proc.Natl.Acad.Sci.USA, 1980;77:5754

Product Datasheets

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Citation for [Nle4,D-Phe7]-α-MSH

The citations listed below are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:

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