Biological Activity[Nle4,D-Phe7]-α-MSH is a synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).
(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Melanocortin receptors: perspectives for novel drugs.
4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity.
Sawyer et al.
Citation for [Nle4,D-Phe7]-α-MSH
The citations listed below are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:
1 Citation: Showing 1 - 1
Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
Authors: Schellekens Et al.
J Biol Chem 2013;288:181
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