Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N
-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β
and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.
Soluble to 30 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin.
Patti et al.
N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Edsall et al.
N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets.
Yatomi et al.