N,N-Dimethylsphingosine

Catalog # Availability Size / Price Qty
4640/10
Cat.No. 4640 - N,N-Dimethylsphingosine | C20H41NO2 | CAS No. 119567-63-4
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Description: Sphingosine kinase inhibitor

Chemical Name: (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol

Purity: ≥98%

Product Details
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Biological Activity

Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.

Technical Data

M.Wt:
327.55
Formula:
C20H41NO2
Solubility:
Soluble to 30 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
119567-63-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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