Potent inhibitor of noradrenalin and dopamine uptake (Ki
values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.
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All Tocris products are intended for laboratory research use only.
Nomifensine and its derivatives as possible tools for studying amine uptake.
Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats.
Nakachi et al.
Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons.
Katz et al.
The citations listed below are publications that use Tocris products. Selected citations for Nomifensine include:
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