Nomifensine

Key Product Details

Product Description

Nomifensine is a potent inhibitor of noradrenaline and dopamine uptake (K_i values are 4.7, 26 and 4000 nM for inhibition of noradrenaline, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.

Product Specifications for Nomifensine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Nomifensine

The following data is based on the product molecular weight 354.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.11 mL	28.22 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 137 publications citing the usage of this product.

• Nakachi Effects of various DA uptake inhibitors on striatal extracellular DA levels and behaviours in rats. Eur.J.Pharmacol. 1995 PMID: 7589207
• Katz Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 2010 PMID: 19939862
• Tuomisto Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 1977 PMID: 844493

Product Documents for Nomifensine