Chemical Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate
Biological ActivityPotent inhibitor of noradrenalin and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Nomifensine and its derivatives as possible tools for studying amine uptake.
Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats.
Nakachi et al.
Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons.
Katz et al.
Citation for Nomifensine
The citations listed below are publications that use Tocris products. Selected citations for Nomifensine include:
1 Citation: Showing 1 - 1
Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
Authors: Zapata Et al.
J Biol Chem 2007;282:35842
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