Nor NOHA monoacetate

Catalog # Availability Size / Price Qty
Nor NOHA monoacetate | CAS No. 2250019-93-1 | Hydrolase Inhibitors
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Description: Arginase inhibitor

Chemical Name: (2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate

Product Details

Biological Activity

Nor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC50 = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.

Technical Data

Soluble to 100 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The new α-amino acid Nω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster.
    Custot et al.
    J.Am.Chem.Soc., 1997;119:4086
  2. Classical and slow-binding inhibitors of human type II arginase.
    Colleluori and Ash et al.
    Biochemistry, 2001;40:9356
  3. The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries.
    Huynh et al.
    Br.J.Pharmacol., 2009;156:84
  4. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.
    Rodriguez et al.
    Cancer Res., 2004;64:5839

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