Nor NOHA monoacetate
Chemical Name: (2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate
Biological ActivityNor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC50 = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The new α-amino acid Nω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster.
Custot et al.
Classical and slow-binding inhibitors of human type II arginase.
Colleluori and Ash et al.
The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries.
Huynh et al.
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.
Rodriguez et al.
Cancer Res., 2004;64:5839
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